In vivo testing of oral iron chelators intended for clinical use [letter; comment]

In vivo testing of oral iron chelators intended for clinical use.

The effectiveness of 1,2-dimethyl-3-hydroxypyrid-4-one (Ll) in increasing iron excretion in iron-loaded patients improved the propsects for replacing desferrioxamine (DF) with an oral chelating drug.’,’ L1 belongs to a new group of iron chelators, the a-ketohydroxypyridines (KHP); which are cheap to p ~ e p a r e ~ . ~ and orally active. Recently, a detailed article by Porter et al.’ on in vivo...

Real-world use of iron chelators.

Whereas RBC transfusion therapy is lifesaving in thalassemia, obligatory iron loading accompanies such treatment and chelation therapy to remove and detoxify iron resulting from these chronic transfusions must therefore be administered. Morbidity and mortality in thalassemia is linked closely to the adequacy of chelation. Three chelators are currently available worldwide-deferoxamine, deferasir...

Oral iron chelators: new opportunities and new dilemmas.

assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.

چکیده ندارد.

Guideline on immunogenicity assessment of monoclonal antibodies intended for in-vivo clinical use